|
gptkbp:instanceOf
|
gptkb:protein
pattern recognition receptor
|
|
gptkbp:activatedBy
|
gptkb:NF-kappaB_pathway
|
|
gptkbp:alternativeName
|
gptkb:TLR2
gptkb:CD282
|
|
gptkbp:associatedWith
|
sepsis
autoimmune diseases
inflammatory diseases
|
|
gptkbp:binds
|
gptkb:lipoteichoic_acid
peptidoglycan
bacterial lipoproteins
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:domain
|
leucine-rich repeat
TIR domain
|
|
gptkbp:encodedBy
|
gptkb:TLR2_gene
|
|
gptkbp:Entrez_Gene_ID
|
7097
|
|
gptkbp:expressedIn
|
dendritic cells
macrophages
monocytes
epithelial cells
neutrophils
|
|
gptkbp:formsHeterodimerWith
|
Toll-like receptor 1
Toll-like receptor 6
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
activation of innate immune response
recognition of pathogen-associated molecular patterns
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Toll-like receptor 2
|
|
gptkbp:interactsWith
|
gptkb:CD14
MyD88
TIRAP
|
|
gptkbp:length
|
784 amino acids
|
|
gptkbp:locatedOn
|
cell surface
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4_(human)
|
|
gptkbp:modulatedBy
|
cytokine production
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:OMIM
|
603028
|
|
gptkbp:partOf
|
innate immune system
|
|
gptkbp:PDB
|
2Z7X
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:reviewedBy
|
gptkb:Immunity
gptkb:Nature
Cell
|
|
gptkbp:speciesHomolog
|
mouse Tlr2
rat Tlr2
|
|
gptkbp:UniProtID
|
O60603
|
|
gptkbp:bfsParent
|
gptkb:Lipoarabinomannan
|
|
gptkbp:bfsLayer
|
7
|