|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Toll-like_receptor_2
|
|
gptkbp:associatedWith
|
infectious diseases
autoimmune diseases
inflammatory diseases
|
|
gptkbp:cellSurfaceMarker
|
dendritic cells
macrophages
monocytes
neutrophils
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodedBy
|
gptkb:TLR2_gene
|
|
gptkbp:expressedIn
|
immune cells
|
|
gptkbp:extracellularDomain
|
leucine-rich repeats
|
|
gptkbp:formsHeterodimerWith
|
gptkb:TLR1
gptkb:TLR6
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:function
|
activation of innate immune response
recognition of pathogen-associated molecular patterns
|
|
gptkbp:gene
|
gptkb:TLR2
|
|
gptkbp:HGNC_ID
|
11848
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD282
|
|
gptkbp:intracellularDomain
|
Toll/Interleukin-1 receptor (TIR) domain
|
|
gptkbp:ligand
|
gptkb:lipoarabinomannan
peptidoglycan
bacterial lipoproteins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q31.3
|
|
gptkbp:OMIM
|
603028
|
|
gptkbp:pathway
|
gptkb:NF-kappaB_pathway
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:UniProtID
|
O60603
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:bfsLayer
|
7
|