Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
pattern recognition receptor |
| gptkbp:alternativeName |
TLRs
|
| gptkbp:associatedWith |
infectious diseases
autoimmune diseases inflammatory diseases |
| gptkbp:component |
innate immune system
|
| gptkbp:discoveredBy |
gptkb:Jules_Hoffmann
|
| gptkbp:encodedBy |
TLR genes
|
| gptkbp:expressedIn |
gptkb:B_cells
dendritic cells macrophages epithelial cells |
| gptkbp:firstDescribed |
1997
|
| gptkbp:foundIn |
animals
humans |
| gptkbp:function |
activation of innate immune system
recognition of pathogens |
| https://www.w3.org/2000/01/rdf-schema#label |
Toll-like receptors
|
| gptkbp:involvedIn |
host defense
pathogen recognition immune signaling |
| gptkbp:ligand |
single-stranded RNA
lipopolysaccharide double-stranded RNA flagellin unmethylated CpG DNA |
| gptkbp:locatedIn |
gptkb:cell_membrane
endosomes |
| gptkbp:orthologIn |
Drosophila Toll protein
|
| gptkbp:proteinFamily |
gptkb:TLR2
gptkb:TLR4 gptkb:TLR1 gptkb:TLR10 gptkb:TLR3 gptkb:TLR5 gptkb:TLR6 gptkb:TLR8 gptkb:TLR9 TLR7 |
| gptkbp:regulates |
inflammatory response
cytokine production |
| gptkbp:structure |
transmembrane domain
leucine-rich repeat domain Toll/Interleukin-1 receptor (TIR) domain |
| gptkbp:type |
gptkb:MAPK_pathway
gptkb:NF-κB_pathway IRF pathway |
| gptkbp:bfsParent |
gptkb:LRR
|
| gptkbp:bfsLayer |
6
|