Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:amended_by |
immune tolerance
|
| gptkbp:associated_with |
inflammatory diseases
TLR signaling pathway TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TLR9 |
| gptkbp:bind_to |
pathogen-associated molecular patterns (PAMPs)
|
| gptkbp:can_lead_to |
cytokine storm
|
| gptkbp:community |
T cell responses
|
| gptkbp:consists_of |
multiple subtypes
|
| gptkbp:contribution |
host defense
|
| gptkbp:discovered_by |
gptkb:Charles_Janeway
gptkb:1997 |
| gptkbp:enhances |
antigen presentation
|
| gptkbp:expressed_on |
gptkb:T_cells
B cells macrophages dendritic cells |
| gptkbp:function |
detect pathogens
|
| gptkbp:has_role |
innate immunity
|
| https://www.w3.org/2000/01/rdf-schema#label |
Toll-like receptors
|
| gptkbp:influence |
B cell activation
adaptive immunity |
| gptkbp:initiated_by |
immune response
certain drugs endogenous ligands exogenous ligands |
| gptkbp:interacts_with |
adaptor proteins
|
| gptkbp:involved_in |
metabolic disorders
autoimmune diseases neuroinflammation sepsis vaccine development chronic inflammation host-pathogen interactions translational medicine cancer immunotherapy immune system regulation |
| gptkbp:is_expressed_in |
various tissues
fibroblasts endothelial cells neutrophils epithelial cells stromal cells |
| gptkbp:is_found_in |
gptkb:Cell
|
| gptkbp:is_linked_to |
allergic reactions
|
| gptkbp:is_recognized_by |
gptkb:Drosophila_melanogaster
|
| gptkbp:is_regulated_by |
cellular responses
|
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_targeted_at |
vaccines
therapeutics |
| gptkbp:named_after |
Toll protein
|
| gptkbp:participated_in |
apoptosis
|
| gptkbp:recognizes |
bacterial components
fungal components parasitic components viral components |
| gptkbp:trigger_type |
cytokine production
|
| gptkbp:bfsParent |
gptkb:Jules_Hoffmann
|
| gptkbp:bfsLayer |
5
|