|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
gptkb:SMAD2
gptkb:SMAD3
|
|
gptkbp:alsoKnownAs
|
Transforming Growth Factor-beta pathway
|
|
gptkbp:crossTalksWith
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:database
|
KEGG:hsa04350
Reactome:R-HSA-170834
WikiPathways:WP560
|
|
gptkbp:discoveredBy
|
gptkb:Anita_B._Roberts
gptkb:Michael_B._Sporn
|
|
gptkbp:downstreamEffectorsInclude
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD4
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
autoimmune diseases
fibrosis
|
|
gptkbp:formsComplexWith
|
gptkb:SMAD4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TGF-beta pathway
|
|
gptkbp:importantFor
|
embryonic development
wound healing
tissue homeostasis
|
|
gptkbp:inhibitedBy
|
gptkb:SMAD7
inhibitory SMADs
|
|
gptkbp:involves
|
gptkb:SMAD_proteins
TGF-beta ligands
TGF-beta receptors
|
|
gptkbp:ligandBindsTo
|
gptkb:TGF-beta_receptor_type_II
|
|
gptkbp:ligandsInclude
|
gptkb:TGF-beta1
gptkb:TGF-beta2
gptkb:TGF-beta3
|
|
gptkbp:modulatedBy
|
gene expression
phosphorylation
sumoylation
ubiquitination
acetylation
microRNAs
|
|
gptkbp:receptorPhosphorylates
|
gptkb:TGF-beta_receptor_type_I
|
|
gptkbp:receptorsInclude
|
gptkb:TGFBR2
gptkb:TGFBR1
gptkb:TGFBR3
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
immune response
extracellular matrix production
|
|
gptkbp:translocatesTo
|
gptkb:nucleus
|
|
gptkbp:bfsParent
|
gptkb:MYC_gene
gptkb:miR-192
gptkb:WWP2
|
|
gptkbp:bfsLayer
|
7
|