|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:TGF-beta_receptor_type_II
TGF-beta RII
TGFR-2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Loeys-Dietz_syndrome
gptkb:hereditary_nonpolyposis_colorectal_cancer
Marfan syndrome type 2
|
|
gptkbp:biologicalProcess
|
apoptosis
differentiation
cell growth regulation
receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:encodes
|
TGF-beta receptor type-2 protein
|
|
gptkbp:Entrez_Gene_ID
|
7048
ENSG00000163513
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
transforming growth factor beta receptor type 2
|
|
gptkbp:function
|
mediates TGF-beta signaling
serine/threonine kinase receptor
|
|
gptkbp:HGNC_ID
|
HGNC:11773
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TGFBR2
|
|
gptkbp:interactsWith
|
gptkb:TGF-beta1
gptkb:TGFBR1
gptkb:SMAD_proteins
|
|
gptkbp:length
|
567 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3p24.1
|
|
gptkbp:mutationAssociatedWith
|
cancer predisposition
|
|
gptkbp:OMIM
|
190182
|
|
gptkbp:orthologInMouse
|
Tgfbr2
|
|
gptkbp:pathway
|
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:UniProtID
|
P37173
|
|
gptkbp:bfsParent
|
gptkb:chromosome_3
|
|
gptkbp:bfsLayer
|
6
|