|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:CED
gptkb:TGFB1
DPD1
Latency-associated peptide
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Marfan_syndrome
autoimmune disease
fibrosis
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodedBy
|
TGFB1 gene
|
|
gptkbp:ensembl
|
ENSG00000105329
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
liver
macrophages
platelets
epithelial cells
|
|
gptkbp:family
|
gptkb:TGF-beta_superfamily
|
|
gptkbp:fullName
|
Transforming Growth Factor Beta 1
|
|
gptkbp:function
|
wound healing
immunosuppression
regulation of cell differentiation
regulation of cell growth
extracellular matrix production
|
|
gptkbp:gene
|
gptkb:TGFB1
|
|
gptkbp:GOID
|
GO:0007179
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TGF-beta1
|
|
gptkbp:locatedOnChromosome
|
19q13.2
|
|
gptkbp:location
|
extracellular space
secreted
|
|
gptkbp:molecularWeight
|
25 kDa (dimer)
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:TGF-beta2
gptkb:TGF-beta3
|
|
gptkbp:pathway
|
gptkb:MAPK_pathway
SMAD signaling pathway
|
|
gptkbp:PDB
|
3KFD
|
|
gptkbp:postTranslationalModification
|
cleavage
glycosylation
|
|
gptkbp:recipient
|
gptkb:TGF-beta_receptor_type_I
gptkb:TGF-beta_receptor_type_II
|
|
gptkbp:RefSeq
|
NP_000651.3
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
angiogenesis
inflammation
immune response
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
P01137
|
|
gptkbp:bfsParent
|
gptkb:ENG_gene
gptkb:TGF-beta_signaling_pathway
gptkb:TGF-beta_superfamily
gptkb:TGF-beta_receptor
gptkb:TGFBR2
|
|
gptkbp:bfsLayer
|
7
|