|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:TGF-beta_type_I_receptor
ALK-5
SKR4
|
|
gptkbp:biologicalProcess
|
signal transduction
regulation of apoptosis
regulation of cell differentiation
regulation of cell proliferation
protein serine/threonine kinase activity
transmembrane receptor protein kinase activity
|
|
gptkbp:encodes
|
TGF-beta receptor type-1 protein
|
|
gptkbp:Entrez_Gene_ID
|
7046
ENSG00000106799
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Transforming growth factor beta receptor type 1
|
|
gptkbp:function
|
serine/threonine kinase activity
TGF-beta receptor activity
|
|
gptkbp:HGNC_ID
|
gptkb:TGFBR1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TGFBR1
|
|
gptkbp:interactsWith
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:TGFBR2
gptkb:SMAD4
|
|
gptkbp:involvedIn
|
gptkb:TGF-beta_signaling_pathway
apoptosis
cell differentiation
immune response
cell growth regulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q22
9
chr9:101867726-101916432
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Loeys-Dietz_syndrome
gptkb:hereditary_hemorrhagic_telangiectasia
various cancers
|
|
gptkbp:OMIM
|
190181
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:partOf
|
TGF-beta receptor complex
|
|
gptkbp:PDB
|
1PY5
1RW8
3KFD
|
|
gptkbp:phosphorylates
|
gptkb:SMAD2
gptkb:SMAD3
|
|
gptkbp:RefSeq
|
NM_004612
|
|
gptkbp:regulates
|
cell cycle
immune cell function
extracellular matrix production
|
|
gptkbp:UniProtID
|
P36897
|
|
gptkbp:bfsParent
|
gptkb:MADH4
gptkb:Mothers_against_decapentaplegic_homolog_4
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD4_gene
gptkb:TGF-beta_receptor_family
gptkb:TGF-beta_signaling_pathway
gptkb:TGF-beta_receptor
gptkb:TGFBR2
|
|
gptkbp:bfsLayer
|
7
|