|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Syk_kinase
gptkb:SYK_tyrosine_kinase
|
|
gptkbp:associatedWith
|
gptkb:ZAP-70
|
|
gptkbp:discoveredBy
|
gptkb:T._Kurosaki_et_al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000165025
|
|
gptkbp:enzymeClassification
|
EC 2.7.10.2
|
|
gptkbp:expressedIn
|
gptkb:B_cells
myeloid cells
|
|
gptkbp:fullName
|
gptkb:Spleen_tyrosine_kinase
|
|
gptkbp:function
|
signal transduction
immune cell activation
|
|
gptkbp:gene
|
SYK
|
|
gptkbp:HGNC_ID
|
11491
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Syk
|
|
gptkbp:inhibitedBy
|
gptkb:entospletinib
gptkb:fostamatinib
|
|
gptkbp:interactsWith
|
gptkb:Vav1
gptkb:BLNK
gptkb:PLCĪ³2
gptkb:Lyn
gptkb:LAT
gptkb:CD79A
gptkb:CD79B
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q22
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
impaired B cell development
|
|
gptkbp:OMIM
|
600085
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Syk_(Mus_musculus)
|
|
gptkbp:pathway
|
gptkb:B_cell_receptor_signaling_pathway
Fc receptor signaling pathway
|
|
gptkbp:PDB
|
gptkb:4PUZ
|
|
gptkbp:phosphorylates
|
ITAM motifs
Y348
Y352
Y525
Y526
|
|
gptkbp:RefSeq
|
NM_003177
|
|
gptkbp:role
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:structure
|
contains SH2 domains
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:targetOfDrug
|
gptkb:entospletinib
gptkb:fostamatinib
|
|
gptkbp:UniProtID
|
gptkb:P43405
|
|
gptkbp:bfsParent
|
gptkb:planet_Mongo
gptkb:PAX5
|
|
gptkbp:bfsLayer
|
7
|