Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:abbreviation |
SYK
|
| gptkbp:associatedWith |
autoimmune diseases
hematological malignancies |
| gptkbp:biologicalProcess |
gptkb:B_cell_receptor_signaling_pathway
protein tyrosine kinase activity Fc receptor signaling pathway |
| gptkbp:cellularComponent |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:discoveredBy |
1991
|
| gptkbp:EC_number |
2.7.10.2
|
| gptkbp:encodedBy |
SYK gene
|
| gptkbp:function |
signal transduction
immune cell activation |
| https://www.w3.org/2000/01/rdf-schema#label |
Spleen tyrosine kinase
|
| gptkbp:inhibitedBy |
gptkb:entospletinib
gptkb:fostamatinib |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_9q22
|
| gptkbp:molecularWeight |
72 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
Mus musculus Syk
|
| gptkbp:PDB |
gptkb:4PUZ
|
| gptkbp:structure |
contains SH2 domains
|
| gptkbp:UniProtID |
gptkb:P43405
|
| gptkbp:bfsParent |
gptkb:Syk
gptkb:Syk_kinase |
| gptkbp:bfsLayer |
8
|