|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:Spleen_tyrosine_kinase
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
kinase domain
SH2 domain
|
|
gptkbp:EC_number
|
2.7.10.2
|
|
gptkbp:encodedBy
|
SYK gene
|
|
gptkbp:Entrez_Gene_ID
|
6850
ENSG00000165025
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:GO_term
|
GO:0005737
GO:0007169
GO:0004715
|
|
gptkbp:hasIsoform
|
SYK(L)
SYK(S)
|
|
gptkbp:hasPfamID
|
gptkb:PF07714
PF00017
|
|
gptkbp:hasRefSeqID
|
NP_003168.2
|
|
gptkbp:HGNC_ID
|
11491
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SYK tyrosine kinase
|
|
gptkbp:InterPro
|
IPR000980
|
|
gptkbp:involvedIn
|
gptkb:B_cell_receptor_signaling_pathway
immune response
|
|
gptkbp:KEGGID
|
hsa:6850
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q22
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:OMIM
|
600085
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:4PUZ
1XBA
|
|
gptkbp:phosphorylates
|
ITAM motifs
|
|
gptkbp:Reactome
|
R-HSA-202430
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
|
|
gptkbp:significance
|
leukemia
autoimmune diseases
|
|
gptkbp:target
|
gptkb:entospletinib
gptkb:fostamatinib
|
|
gptkbp:UniProtID
|
gptkb:P43405
|
|
gptkbp:bfsParent
|
gptkb:Syk
|
|
gptkbp:bfsLayer
|
8
|