|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:receptor_tyrosine_kinases
immune receptors
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:domain
|
gptkb:PH_domain
C2 domain
SH2 domain
SH3 domain
|
|
gptkbp:encodedBy
|
PLCG2 gene
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
gptkb:B_lymphocytes
gptkb:mast_cells
dendritic cells
hematopoietic cells
myeloid cells
monocytes
neutrophils
|
|
gptkbp:fullName
|
Phospholipase C gamma 2
|
|
gptkbp:function
|
generates second messengers IP3 and DAG
hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2)
|
|
gptkbp:gene
|
gptkb:PLCG2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCγ2
|
|
gptkbp:interactsWith
|
gptkb:Vav1
gptkb:PI3K
gptkb:BLNK
gptkb:Grb2
gptkb:LAT
|
|
gptkbp:involvedIn
|
immune response
B cell receptor signaling
Fc receptor signaling
|
|
gptkbp:locatedOnChromosome
|
16q23.3
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
148 kDa
|
|
gptkbp:mutationAssociatedWith
|
autoinflammatory diseases
PLAID (PLCγ2-associated antibody deficiency and immune dysregulation)
APLAID (autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation)
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2FJU
2OJJ
2OJK
|
|
gptkbp:phosphorylates
|
gptkb:Syk_kinase
Btk kinase
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
calcium signaling
PKC activation
|
|
gptkbp:UniProtID
|
P16885
|
|
gptkbp:bfsParent
|
gptkb:PLCγ
|
|
gptkbp:bfsLayer
|
7
|