|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:Spleen_tyrosine_kinase
SYK
|
|
gptkbp:associatedWith
|
leukemia
autoimmune diseases
rheumatoid arthritis
immune thrombocytopenia
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
T. Kurosaki
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
kinase domain
SH2 domain
|
|
gptkbp:encodedBy
|
SYK gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.10.2
|
|
gptkbp:expressedIn
|
gptkb:B_lymphocytes
gptkb:mast_cells
macrophages
hematopoietic cells
neutrophils
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:hasIsoform
|
SYK(L)
SYK(S)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Syk kinase
|
|
gptkbp:inhibitedBy
|
gptkb:entospletinib
gptkb:fostamatinib
R406
|
|
gptkbp:interactsWith
|
gptkb:Vav1
gptkb:BLNK
gptkb:PLCĪ³2
gptkb:Lyn
gptkb:LAT
|
|
gptkbp:involvedIn
|
gptkb:B_cell_receptor_signaling_pathway
immune response
Fc receptor signaling pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q22
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:orthologIn
|
mouse Syk
rat Syk
|
|
gptkbp:PDB
|
gptkb:4PUZ
4XG9
|
|
gptkbp:phosphorylates
|
ITAM motifs
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
inflammatory response
|
|
gptkbp:target
|
gptkb:fostamatinib
|
|
gptkbp:UniProtID
|
gptkb:P43405
|
|
gptkbp:bfsParent
|
gptkb:CD79b
gptkb:B_cell_receptor_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|