Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:composedOf |
gptkb:TGF-beta_type_III_receptor
gptkb:TGF-beta_type_II_receptor gptkb:TGF-beta_type_I_receptor |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
binds TGF-beta ligands
initiates TGF-beta signaling pathway |
| gptkbp:GO_term |
gptkb:GO:0005024
|
| gptkbp:hasMember |
gptkb:ALK1
gptkb:TGFBR2 gptkb:ALK5 gptkb:TGFBR1 gptkb:TGFBR3 |
| https://www.w3.org/2000/01/rdf-schema#label |
TGF-beta receptor family
|
| gptkbp:involvedIn |
apoptosis
differentiation immune response cell growth regulation fibrosis |
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:mutationAssociatedWith |
gptkb:Loeys-Dietz_syndrome
gptkb:cancer gptkb:Marfan_syndrome |
| gptkbp:relatedTo |
gptkb:SMAD_proteins
serine/threonine kinase activity |
| gptkbp:bfsParent |
gptkb:ACVRL1
|
| gptkbp:bfsLayer |
6
|