|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:BMP_receptors
TGF-beta receptors
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:category
|
transcription factors
signal transducers
|
|
gptkbp:contains
|
MH1 domain
MH2 domain
|
|
gptkbp:database
|
GeneCards:SMAD
HGNC:6767
UniProt:Q15796
|
|
gptkbp:firstDescribed
|
1996
|
|
gptkbp:formsComplexWith
|
other SMAD proteins
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD
|
|
gptkbp:humanGeneExamples
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD1
gptkb:SMAD5
gptkb:SMAD6
gptkb:SMAD7
gptkb:SMAD8
gptkb:SMAD9
gptkb:SMAD4
|
|
gptkbp:inhibitedBy
|
gptkb:I-SMADs
|
|
gptkbp:involvedIn
|
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:mutationAssociatedWith
|
gptkb:juvenile_polyposis_syndrome
gptkb:cancer
gptkb:hereditary_hemorrhagic_telangiectasia
|
|
gptkbp:namedAfter
|
gptkb:Mothers_against_decapentaplegic
|
|
gptkbp:orthologIn
|
gptkb:Drosophila
gptkb:C._elegans
vertebrates
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:relatedTo
|
gptkb:C._elegans_Sma_protein
gptkb:Drosophila_Mad_protein
|
|
gptkbp:role
|
gptkb:cancer
apoptosis
embryonic development
cell growth
immune regulation
fibrosis
|
|
gptkbp:type
|
gptkb:Co-SMAD
gptkb:I-SMAD
gptkb:R-SMAD
|
|
gptkbp:bfsParent
|
gptkb:Soviet_Military_Administration_in_Germany
|
|
gptkbp:bfsLayer
|
6
|