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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:activatedBy
|
phosphorylation
|
|
gptkbp:category
|
intracellular proteins
|
|
gptkbp:database
|
HGNC:6767
GeneCards:SMAD_family
|
|
gptkbp:discoveredBy
|
gptkb:Joan_Massagué
|
|
gptkbp:firstDescribed
|
1995
|
|
gptkbp:foundIn
|
animals
|
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gptkbp:function
|
signal transduction
transcription regulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD genes
|
|
gptkbp:interactsWith
|
TGF-beta receptors
co-SMADs
inhibitory SMADs
|
|
gptkbp:involvedIn
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:member
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:SMAD1
gptkb:SMAD5
gptkb:SMAD6
gptkb:SMAD7
gptkb:SMAD8
gptkb:SMAD9
gptkb:SMAD4
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
impaired signaling
|
|
gptkbp:namedAfter
|
C. elegans gene 'SMA'
Drosophila gene 'Mothers against decapentaplegic'
|
|
gptkbp:numberOfMembers
|
8 in humans
|
|
gptkbp:orthologIn
|
gptkb:Drosophila
gptkb:C._elegans
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:relatedTo
|
apoptosis
differentiation
cell growth
embryogenesis
|
|
gptkbp:role
|
gptkb:cancer
developmental disorders
fibrosis
|
|
gptkbp:subclassOf
|
gptkb:Co-SMADs
gptkb:I-SMADs
gptkb:R-SMADs
|
|
gptkbp:bfsParent
|
gptkb:SMAD_family
|
|
gptkbp:bfsLayer
|
7
|