|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
resveratrol
|
|
gptkbp:alias
|
gptkb:SIR2L2
SIR2-like protein 2
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:discoveredBy
|
Landry J et al.
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodes
|
Sirtuin 2
|
|
gptkbp:Entrez_Gene_ID
|
22933
ENSG00000196591
|
|
gptkbp:expressedIn
|
gptkb:testis
brain
liver
|
|
gptkbp:function
|
regulation of cell cycle
regulation of microtubule dynamics
NAD-dependent deacetylase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:14930
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT2 gene
|
|
gptkbp:inhibitedBy
|
gptkb:AGK2
gptkb:SirReal2
gptkb:AK-7
|
|
gptkbp:length
|
389 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:molecularWeight
|
43 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
glioma
|
|
gptkbp:OMIM
|
604144
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Sirt2
|
|
gptkbp:pathway
|
DNA repair
cellular senescence
metabolic regulation
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:proteinFamily
|
sirtuin family
sirtuin catalytic domain
|
|
gptkbp:regulates
|
mitosis
oxidative stress response
acetylation of alpha-tubulin
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:UniProtID
|
Q8IXJ6
|
|
gptkbp:bfsParent
|
gptkb:SIRT2
|
|
gptkbp:bfsLayer
|
8
|