|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PAI1
gptkb:plasminogen_activator_inhibitor_type_1
gptkb:serpin_E1
|
|
gptkbp:associatedWith
|
gptkb:metabolic_syndrome
thrombosis
fibrosis
|
|
gptkbp:encodes
|
gptkb:plasminogen_activator_inhibitor-1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000106366
5054
|
|
gptkbp:expressedIn
|
liver
adipose tissue
endothelial cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:8583
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SERPINE1
|
|
gptkbp:inhibitedBy
|
gptkb:tissue_plasminogen_activator
gptkb:urokinase
|
|
gptkbp:length
|
402
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q22.1
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:mutationAssociatedWith
|
bleeding disorder
|
|
gptkbp:OMIM
|
173360
|
|
gptkbp:orthologInMouse
|
gptkb:Serpine1
|
|
gptkbp:product
|
gptkb:PAI-1
|
|
gptkbp:regulates
|
gptkb:insulin
gptkb:TGF-beta
fibrinolysis
inflammatory cytokines
|
|
gptkbp:significance
|
implicated in cancer progression
marker for metabolic syndrome
risk factor for cardiovascular disease
|
|
gptkbp:UniProtID
|
gptkb:P05121
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:P05177
|
|
gptkbp:bfsLayer
|
6
|