|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PAI-1
gptkb:plasminogen_activator_inhibitor_type_1
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:metabolic_syndrome
thrombosis
|
|
gptkbp:biologicalProcess
|
blood coagulation
negative regulation of fibrinolysis
serine-type endopeptidase inhibitor activity
|
|
gptkbp:encodes
|
gptkb:plasminogen_activator_inhibitor-1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000106366
5054
|
|
gptkbp:expressedIn
|
liver
adipose tissue
macrophages
platelets
endothelial cells
fibroblasts
smooth muscle cells
|
|
gptkbp:firstDescribed
|
1984
|
|
gptkbp:function
|
gptkb:serine_protease
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:8583
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Serpine1
|
|
gptkbp:inhibitedBy
|
fibrinolysis
|
|
gptkbp:length
|
402 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q22.1
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased risk of thrombosis
|
|
gptkbp:OMIM
|
173360
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Serpine1 (mouse)
Serpine1 (rat)
|
|
gptkbp:product
|
PAI-1 protein
|
|
gptkbp:protein_structure
|
contains serpin domain
|
|
gptkbp:proteinFamily
|
serpin family
|
|
gptkbp:regulates
|
gptkb:tissue_plasminogen_activator
gptkb:urokinase
fibrinolysis
|
|
gptkbp:significance
|
marker for cardiovascular risk
target for anti-thrombotic therapy
|
|
gptkbp:transcription_regulated_by
|
gptkb:insulin
gptkb:TGF-beta
gptkb:glucocorticoids
inflammatory cytokines
|
|
gptkbp:UniProtID
|
gptkb:P05121
|
|
gptkbp:bfsParent
|
gptkb:SERPINE1
|
|
gptkbp:bfsLayer
|
7
|