|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:plasminogen_activator_inhibitor_type_1
gptkb:SERPINE1
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:metabolic_syndrome
thrombosis
|
|
gptkbp:encodedBy
|
SERPINE1 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000106366
5054
|
|
gptkbp:expressedIn
|
liver
adipose tissue
endothelial cells
|
|
gptkbp:family
|
serpin family
|
|
gptkbp:foundIn
|
gptkb:plasma
platelets
|
|
gptkbp:fullName
|
gptkb:plasminogen_activator_inhibitor-1
|
|
gptkbp:function
|
inhibits tissue plasminogen activator (tPA)
inhibits urokinase (uPA)
regulates fibrinolysis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:halfLife
|
1-2 hours in plasma
|
|
gptkbp:HGNC_ID
|
gptkb:SERPINE1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PAI1
|
|
gptkbp:inhibitedBy
|
fibrinolysis
serine proteases
|
|
gptkbp:interactsWith
|
gptkb:uPA
gptkb:tPA
vitronectin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q22.1
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:mutationAssociatedWith
|
deficiency leads to bleeding disorders
overexpression leads to thrombophilia
|
|
gptkbp:OMIM
|
173360
|
|
gptkbp:orthologInMouse
|
gptkb:Serpine1
|
|
gptkbp:PDB
|
1B3K
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
NM_000602
|
|
gptkbp:regulates
|
induced by glucocorticoids
induced by inflammatory cytokines
induced by TGF-beta
induced by insulin
|
|
gptkbp:significance
|
marker for risk of thrombosis
target for anti-thrombotic therapy
|
|
gptkbp:structure
|
contains reactive center loop
|
|
gptkbp:UniProtID
|
gptkb:P05121
|
|
gptkbp:bfsParent
|
gptkb:SERPINE1
|
|
gptkbp:bfsLayer
|
7
|