plasminogen activator inhibitor-1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:PAI-1
gptkbp:alternativeName	gptkb:PAI1 gptkb:plasminogen_activator_inhibitor_type_1 gptkb:serpin_E1
gptkbp:associatedWith	gptkb:cardiovascular_disease gptkb:metabolic_syndrome obesity insulin resistance
gptkbp:encodedBy	SERPINE1 gene
gptkbp:Entrez_Gene_ID	5054
gptkbp:foundIn	adipose tissue blood plasma platelets endothelial cells
gptkbp:function	inhibits tissue plasminogen activator inhibits urokinase
https://www.w3.org/2000/01/rdf-schema#label	plasminogen activator inhibitor-1
gptkbp:inhibitedBy	fibrinolysis
gptkbp:locatedOnChromosome	7q22.1
gptkbp:medicalUse	biomarker for thrombosis risk
gptkbp:memberOf	serpin family
gptkbp:molecularWeight	45 kDa
gptkbp:OMIM	173360
gptkbp:regulates	gptkb:insulin gptkb:angiotensin_II gptkb:TGF-beta gptkb:glucocorticoids inflammatory cytokines
gptkbp:role	thrombosis fibrinolysis
gptkbp:structure	single-chain glycoprotein
gptkbp:UniProtID	gptkb:P05121
gptkbp:bfsParent	gptkb:PAI-1 gptkb:SERPINE1 gptkb:plasminogen_activator gptkb:serpins
gptkbp:bfsLayer	7