tissue plasminogen activator

URI: https://gptkb.org/entity/tissue_plasminogen_activator
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName thrombolytic_agent
gptkbp:approvedBy gptkb:FDA
gptkbp:approvedDrugName gptkb:alteplase
gptkb:reteplase
gptkb:tenecteplase
gptkbp:CASNumber 105857-23-6
gptkbp:category gptkb:tissue_plasminogen_activator
gptkb:drug
gptkbp:contraindication hemorrhagic stroke
active internal bleeding
gptkbp:discoveredBy gptkb:S._Sherry
gptkbp:discoveredIn 1979
gptkbp:EC_number 3.4.21.68
gptkbp:encodedBy gptkb:PLAT_gene
gptkbp:foundIn endothelial cells
gptkbp:function gptkb:serine_protease
converts plasminogen to plasmin
gptkbp:halfLife ~5 minutes
https://www.w3.org/2000/01/rdf-schema#label tissue plasminogen activator
gptkbp:locatedOnChromosome gptkb:chromosome_8p12-p11.2
gptkbp:molecularWeight ~70 kDa
gptkbp:riskFactor bleeding
gptkbp:role fibrinolysis
gptkbp:structure single-chain glycoprotein
gptkbp:symbol gptkb:tPA
gptkbp:UniProtID P00750
gptkbp:usedFor treatment of pulmonary embolism
treatment of ischemic stroke
treatment of myocardial infarction
gptkbp:bfsParent gptkb:Palade_bodies
gptkb:Activase
gptkbp:bfsLayer 6