|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:abbreviation
|
gptkb:uPA
|
|
gptkbp:alternativeName
|
gptkb:urokinase-type_plasminogen_activator
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
B01AD04
|
|
gptkbp:CASNumber
|
9039-53-6
|
|
gptkbp:category
|
gptkb:protein
gptkb:serine_protease
gptkb:enzyme
thrombolytic drug
|
|
gptkbp:contraindication
|
recent stroke
active internal bleeding
severe uncontrolled hypertension
|
|
gptkbp:discoveredBy
|
1947
|
|
gptkbp:EC_number
|
3.4.21.73
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
blood plasma
human urine
|
|
gptkbp:function
|
converts plasminogen to plasmin
involved in fibrinolysis
|
|
gptkbp:gene
|
gptkb:PLAU
|
|
gptkbp:halfLife
|
16 minutes
|
|
gptkbp:hasWikipediaPage
|
https://en.wikipedia.org/wiki/Urokinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
urokinase
|
|
gptkbp:inhibitedBy
|
gptkb:plasminogen_activator_inhibitor-1
plasminogen activator inhibitor-2
|
|
gptkbp:medicalUse
|
gptkb:tissue_plasminogen_activator
treatment of deep vein thrombosis
treatment of pulmonary embolism
treatment of myocardial infarction
|
|
gptkbp:MeSH_ID
|
D014538
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:PDB
|
1OWE
|
|
gptkbp:producedBy
|
recombinant DNA technology
kidney cells
|
|
gptkbp:product
|
plasmin
|
|
gptkbp:PubChem_CID
|
CHEBI:9456
|
|
gptkbp:role_in_cancer
|
involved in tumor invasion and metastasis
|
|
gptkbp:routeOfAdministration
|
intravenous
catheter-directed
|
|
gptkbp:sideEffect
|
bleeding
allergic reaction
|
|
gptkbp:structure
|
gptkb:serine_protease
|
|
gptkbp:substrate
|
gptkb:plasminogen
|
|
gptkbp:UNII
|
G3J0D6RU7J
|
|
gptkbp:UniProtID
|
gptkb:P00749
|
|
gptkbp:used_in
|
fibrinolytic therapy
|
|
gptkbp:bfsParent
|
gptkb:EC_3.4.21.26
gptkb:PLAU
gptkb:SERPINE1
gptkb:plasminogen_activator
|
|
gptkbp:bfsLayer
|
7
|