Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:plasminogen_activator_inhibitor_type_1
gptkb:SERPINE1 endothelial plasminogen activator inhibitor |
| gptkbp:associatedWith |
gptkb:cardiovascular_disease
gptkb:metabolic_syndrome thrombosis |
| gptkbp:discoveredBy |
Erik G. Eriksson
|
| gptkbp:discoveredIn |
1984
|
| gptkbp:expressedIn |
liver
adipose tissue endothelial cells |
| gptkbp:fullName |
gptkb:plasminogen_activator_inhibitor-1
|
| gptkbp:function |
inhibits tissue plasminogen activator (tPA)
inhibits urokinase (uPA) |
| gptkbp:gene |
gptkb:SERPINE1
|
| gptkbp:halfLife |
1-2 hours in plasma
|
| https://www.w3.org/2000/01/rdf-schema#label |
PAI-1
|
| gptkbp:inhibitedBy |
fibrinolysis
|
| gptkbp:inhibitorOf |
serine proteases
plasminogen activators |
| gptkbp:location |
gptkb:chromosome_7q21.3
|
| gptkbp:medicalUse |
biomarker for cardiovascular risk
target for anti-thrombotic therapy |
| gptkbp:molecularWeight |
45 kDa
|
| gptkbp:mutationAssociatedWith |
can cause bleeding disorders
can increase risk of thrombosis |
| gptkbp:OMIM |
173360
|
| gptkbp:orthologIn |
gptkb:mouse
right bovine |
| gptkbp:PDB |
1B3K
|
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation |
| gptkbp:proteinFamily |
serpin
|
| gptkbp:regulates |
induced by glucocorticoids
induced by inflammatory cytokines induced by TGF-beta induced by insulin |
| gptkbp:role |
regulation of fibrinolysis
|
| gptkbp:significance |
elevated in cancer
elevated in sepsis elevated in acute coronary syndrome elevated in obesity elevated in pregnancy elevated in type 2 diabetes |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
serpin superfamily
|
| gptkbp:UniProtID |
gptkb:P05121
|
| gptkbp:bfsParent |
gptkb:P05177
|
| gptkbp:bfsLayer |
6
|