|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:plasminogen_activator_inhibitor_type_1
gptkb:SERPINE1
endothelial plasminogen activator inhibitor
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:metabolic_syndrome
thrombosis
|
|
gptkbp:discoveredBy
|
Erik G. Eriksson
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:expressedIn
|
gptkb:adipose_tissue
liver
endothelial cells
|
|
gptkbp:fullName
|
gptkb:plasminogen_activator_inhibitor-1
|
|
gptkbp:function
|
inhibits tissue plasminogen activator (tPA)
inhibits urokinase (uPA)
|
|
gptkbp:gene
|
gptkb:SERPINE1
|
|
gptkbp:halfLife
|
1-2 hours in plasma
|
|
gptkbp:inhibitedBy
|
fibrinolysis
|
|
gptkbp:inhibitorOf
|
serine proteases
plasminogen activators
|
|
gptkbp:location
|
gptkb:chromosome_7q21.3
|
|
gptkbp:medicalUse
|
biomarker for cardiovascular risk
target for anti-thrombotic therapy
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause bleeding disorders
can increase risk of thrombosis
|
|
gptkbp:OMIM
|
173360
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:right
bovine
|
|
gptkbp:PDB
|
1B3K
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:serpin
|
|
gptkbp:regulates
|
induced by glucocorticoids
induced by inflammatory cytokines
induced by TGF-beta
induced by insulin
|
|
gptkbp:role
|
regulation of fibrinolysis
|
|
gptkbp:significance
|
elevated in cancer
elevated in sepsis
elevated in acute coronary syndrome
elevated in obesity
elevated in pregnancy
elevated in type 2 diabetes
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
serpin superfamily
|
|
gptkbp:UniProtID
|
gptkb:P05121
|
|
gptkbp:bfsParent
|
gptkb:SERPINE1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PAI-1
|