|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PI3K_pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:AKT2
gptkb:RAC-beta_serine/threonine-protein_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes_mellitus
insulin resistance
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
gptkb:PH_domain
kinase domain
regulatory domain
|
|
gptkbp:encodedBy
|
gptkb:AKT2_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
gptkbp:inhibitedBy
|
phosphatases
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
glucose metabolism
apoptosis regulation
insulin signaling pathway
|
|
gptkbp:locatedOnChromosome
|
19q13.1-q13.2
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:AKT_family
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1O6K
|
|
gptkbp:phosphorylates
|
gptkb:PDK1
gptkb:mTORC2
|
|
gptkbp:regulates
|
cell cycle progression
lipid synthesis
protein synthesis
glycogen synthesis
|
|
gptkbp:substrate
|
gptkb:TSC2
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:MDM2
gptkb:mTOR
AS160
|
|
gptkbp:UniProtID
|
P31751
|
|
gptkbp:bfsParent
|
gptkb:AKT2
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protein kinase B beta
|