|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:FAK
gptkb:Focal_adhesion_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
metastasis
|
|
gptkbp:biologicalProcess
|
cell motility
protein tyrosine kinase activity
focal adhesion assembly
regulation of cell shape
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
focal adhesion
|
|
gptkbp:discoveredBy
|
gptkb:Tony_Hunter
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:FAK
|
|
gptkbp:Entrez_Gene_ID
|
5747
ENSG00000169398
|
|
gptkbp:fullName
|
gptkb:Protein_Tyrosine_Kinase_2
|
|
gptkbp:function
|
signal transduction
cell migration
cell adhesion
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
gptkb:GO:0004713
gptkb:GO:0005925
GO:0007165
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
9611
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTK2
|
|
gptkbp:interactsWith
|
gptkb:integrins
gptkb:SRC
gptkb:paxillin
gptkb:talin
|
|
gptkbp:length
|
1052 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8q24.3
chromosome 8
|
|
gptkbp:molecularWeight
|
119 kDa
|
|
gptkbp:OMIM
|
600758
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ptk2
|
|
gptkbp:PDB
|
gptkb:2AL6
gptkb:4NY0
2J0J
|
|
gptkbp:phosphorylates
|
Y397
Y576
Y577
Y861
Y925
|
|
gptkbp:product
|
gptkb:Focal_adhesion_kinase
|
|
gptkbp:regulates
|
activated by growth factors
activated by integrin clustering
inhibited by small molecule inhibitors
|
|
gptkbp:UniProtID
|
Q05397
|
|
gptkbp:bfsParent
|
gptkb:PTEN
|
|
gptkbp:bfsLayer
|
5
|