phosphatase and tensin homolog

URI: https://gptkb.org/entity/phosphatase_and_tensin_homolog

GPTKB entity

Statements (91)

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene
gptkbp:alias	gptkb:MHAM gptkb:MMAC1 gptkb:TEP1
gptkbp:discoveredBy	gptkb:Paolo_Pandolfi gptkb:Peter_Vogelstein
gptkbp:discoveredIn	1997
gptkbp:domain	C2 domain PDZ-binding motif phosphatase domain
gptkbp:encodedBy	gptkb:PTEN_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000171862 5728
gptkbp:expressedIn	many tissues
gptkbp:function	gptkb:protein tumor suppressor phosphatase activity lipid phosphatase
gptkbp:HGNC_ID	9588
https://www.w3.org/2000/01/rdf-schema#label	phosphatase and tensin homolog
gptkbp:inhibitedBy	phosphorylation
gptkbp:length	403
gptkbp:locatedOnChromosome	gptkb:10q23.3 gptkb:chromosome_10
gptkbp:molecularWeight	47 kDa
gptkbp:mutationAssociatedWith	gptkb:Bannayan–Riley–Ruvalcaba_syndrome gptkb:Lhermitte–Duclos_disease gptkb:cancer gptkb:Cowden_syndrome gptkb:endometrial_cancer gptkb:glioblastoma melanoma prostate cancer
gptkbp:OMIM	601728
gptkbp:orthologInC.elegans	gptkb:daf-18
gptkbp:orthologInFruitFly	dpten
gptkbp:orthologInMouse	Pten
gptkbp:orthologInZebrafish	ptena ptenb
gptkbp:PDB	gptkb:1D5J gptkb:1D5K gptkb:1D5L gptkb:1D5P gptkb:1D5Q gptkb:1D5R gptkb:1D5S gptkb:1D5V gptkb:1D5X 1D50 1D51 1D52 1D53 1D54 1D55 1D56 1D57 1D58 1D59 1D5A 1D5B 1D5C 1D5D 1D5E 1D5F 1D5G 1D5H 1D5I 1D5M 1D5N 1D5O 1D5T 1D5U 1D5Y 1D5Z
gptkbp:regulates	gptkb:PI3K/AKT_signaling_pathway apoptosis cell proliferation cell survival DNA repair metabolism angiogenesis cell growth cell migration cell cycle cell adhesion
gptkbp:symbol	gptkb:PTEN
gptkbp:UniProtID	gptkb:P60484
gptkbp:bfsParent	gptkb:HGNC:9873 gptkb:PTEN
gptkbp:bfsLayer	5