PRDM1

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:BLIMP-1
gptkbp:associatedWith multiple myeloma
diffuse large B-cell lymphoma
immunodeficiency
gptkbp:domain zinc finger domain
PR domain
gptkbp:encodes gptkb:PR_domain_zinc_finger_protein_1
gptkbp:Entrez_Gene_ID gptkb:ENSG00000119715
639
gptkbp:expressedIn plasma cells
lymphoid tissue
gptkbp:function transcriptional repressor
gptkbp:HGNC_ID 9346
https://www.w3.org/2000/01/rdf-schema#label PRDM1
gptkbp:interactsWith gptkb:HDAC2
gptkb:IRF4
gptkb:CBFA2T3
gptkb:G9a
gptkb:PU.1
gptkbp:involvedIn B cell differentiation
plasma cell differentiation
gptkbp:length 825 amino acids
gptkbp:locatedOnChromosome gptkb:6q21
gptkbp:molecularWeight approximately 91 kDa
gptkbp:mutationAssociatedWith leukemia
autoimmune disease
gptkbp:orthologInMouse gptkb:Prdm1
gptkbp:regulates gptkb:interferon-beta
gptkb:c-Myc
gptkb:CIITA
gptkb:PRDM_family
gptkb:PAX5
gptkb:BCL6
apoptosis
cell proliferation
immune response
inflammatory response
cytokine production
germinal center reaction
immune tolerance
T cell homeostasis
T cell exhaustion
immunoglobulin genes
terminal differentiation of B cells
gptkbp:species gptkb:Homo_sapiens
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID gptkb:O75626
gptkbp:bfsParent gptkb:MYB_proto-oncogene,_transcription_factor
gptkbp:bfsLayer 7