PR domain zinc finger protein 1

URI: https://gptkb.org/entity/PR_domain_zinc_finger_protein_1
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:PRDM1
gptkb:BLIMP-1
gptkbp:associatedWith diffuse large B-cell lymphoma
immunodeficiency
gptkbp:domain zinc finger domain
PR domain
gptkbp:encodedBy gptkb:PRDM1_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000119715
639
gptkbp:expressedIn gptkb:B_cells
gptkb:T_cells
dendritic cells
plasma cells
gptkbp:function regulation of immune response
transcriptional repressor
regulation of B cell differentiation
gptkbp:HGNC_ID 9346
https://www.w3.org/2000/01/rdf-schema#label PR domain zinc finger protein 1
gptkbp:interactsWith gptkb:HDAC2
gptkb:IRF4
gptkb:CBFA2T3
gptkb:G9a
gptkb:PU.1
gptkb:BCL6
gptkbp:length 825 amino acids
gptkbp:locatedOnChromosome gptkb:6q21
gptkbp:molecularWeight ~98 kDa
gptkbp:OMIM 603423
gptkbp:organism gptkb:Homo_sapiens
gptkbp:postTranslationalModification phosphorylation
sumoylation
ubiquitination
gptkbp:RefSeq NM_001198
gptkbp:regulates T cell homeostasis
plasma cell differentiation
interferon-beta gene expression
BCL6 gene expression
IRF4 gene expression
MYC gene expression
PRDM1 gene expression (autoregulation)
XBP1 gene expression
germinal center B cell exit
gptkbp:requires immune system development
terminal differentiation of B cells
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID gptkb:O75626
gptkbp:bfsParent gptkb:PRDM1
gptkb:PRDM1_gene
gptkbp:bfsLayer 8