|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:alternativeName
|
SFFV proviral integration oncogene spi-1
SFFV-1
SPI-1
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
immunodeficiency
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:encodedBy
|
SPI1 gene
|
|
gptkbp:Entrez_Gene_ID
|
6688
|
|
gptkbp:expressedIn
|
gptkb:B_lymphocytes
hematopoietic cells
myeloid cells
|
|
gptkbp:family
|
gptkb:ETS_family
|
|
gptkbp:function
|
regulation of gene expression
hematopoietic cell differentiation
|
|
gptkbp:HGNC_ID
|
11240
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PU.1
|
|
gptkbp:interactsWith
|
gptkb:c-Jun
gptkb:IRF4
GATA-1
IRF8
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p11.2
|
|
gptkbp:molecularWeight
|
~31 kDa
|
|
gptkbp:motif
|
gptkb:ETS_domain
|
|
gptkbp:OMIM
|
165170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Spi1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:RefSeq
|
NP_003111.1
|
|
gptkbp:regulates
|
gptkb:CD14
gptkb:CD11b
B cell differentiation
myeloid cell development
immunoglobulin genes
granulocyte differentiation
GM-CSF receptor
IL-7 receptor
M-CSF receptor
dendritic cell differentiation
lymphoid cell development
macrophage differentiation
monocyte differentiation
|
|
gptkbp:structure
|
contains one ETS DNA-binding domain
|
|
gptkbp:UniProtID
|
P17947
|
|
gptkbp:bfsParent
|
gptkb:GATA2
gptkb:RUNX1
|
|
gptkbp:bfsLayer
|
7
|