Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alternativeName |
gptkb:PRDM1
|
| gptkbp:associatedWith |
leukemia
autoimmune diseases |
| gptkbp:discoveredBy |
Kathleen Calame
|
| gptkbp:domain |
zinc finger domain
PR domain |
| gptkbp:encodedBy |
gptkb:PRDM1_gene
|
| gptkbp:Entrez_Gene_ID |
639
|
| gptkbp:expressedIn |
gptkb:B_cells
gptkb:T_cells gptkb:placenta |
| gptkbp:firstDescribed |
1991
|
| gptkbp:function |
transcriptional repressor
|
| gptkbp:HGNC_ID |
9346
|
| https://www.w3.org/2000/01/rdf-schema#label |
BLIMP-1
|
| gptkbp:inhibitedBy |
gptkb:c-Myc
gptkb:CIITA gptkb:PAX5 |
| gptkbp:locatedOnChromosome |
chromosome 6q21
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:regulates |
apoptosis
embryonic development germ cell development immune response immunoglobulin secretion cell cycle arrest cytokine production B cell differentiation hematopoiesis MHC class II expression macrophage polarization plasma cell differentiation dendritic cell function T cell exhaustion interferon response Treg cell function BCL6 expression CD8+ T cell differentiation GZMB expression IL-10 production IRF4 expression NK cell maturation XBP1 expression effector T cell function memory T cell formation |
| gptkbp:UniProtID |
gptkb:O75626
|
| gptkbp:bfsParent |
gptkb:PRDM1
|
| gptkbp:bfsLayer |
8
|