|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
EHMT2
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodevelopmental disorders
|
|
gptkbp:catalyzes
|
methylation of histone H3 at lysine 9 (H3K9)
|
|
gptkbp:encodedBy
|
EHMT2 gene
|
|
gptkbp:Entrez_Gene_ID
|
10919
|
|
gptkbp:enzymeCommissionNumber
|
2.1.1.43
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsComplexWith
|
GLP (EHMT1)
|
|
gptkbp:function
|
histone methyltransferase
|
|
gptkbp:gene
|
EHMT2
|
|
gptkbp:HGNC_ID
|
HGNC:24074
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
G9a
|
|
gptkbp:inhibitedBy
|
gptkb:BIX-01294
gptkb:UNC0638
A-366
BIX-01338
BRD4770
CM-272
MS012
UNC0631
UNC0642
UNC0646
|
|
gptkbp:interactsWith
|
gptkb:DNMT1
HP1
WIZ
|
|
gptkbp:involvedIn
|
chromatin modification
epigenetic gene silencing
transcriptional repression
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
6p21.33
|
|
gptkbp:molecularWeight
|
~160 kDa
|
|
gptkbp:OMIM
|
606646
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ehmt2
|
|
gptkbp:PDB
|
3K5K
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:RefSeq
|
NP_006700.2
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
gene expression
immune response
neuronal differentiation
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:structure
|
contains ankyrin repeats
contains SET domain
|
|
gptkbp:UniProtID
|
Q96KQ7
|
|
gptkbp:bfsParent
|
gptkb:PRDM1
gptkb:H3K9me3
gptkb:DNMT1
gptkb:UNC0638
|
|
gptkbp:bfsLayer
|
8
|