|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
MHC class II transactivator
MHC2TA
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:bare_lymphocyte_syndrome_type_II
autoimmune diseases
immunodeficiency
|
|
gptkbp:discoveredBy
|
Steimle et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
MHC class II transactivator protein
|
|
gptkbp:Entrez_Gene_ID
|
4261
|
|
gptkbp:expressedIn
|
immune cells
|
|
gptkbp:fullName
|
class II, major histocompatibility complex, transactivator
|
|
gptkbp:function
|
transcriptional coactivator
regulation of MHC class II gene expression
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPseudogene
|
no
|
|
gptkbp:HGNC_ID
|
HGNC:7067
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CIITA
|
|
gptkbp:interactsWith
|
gptkb:CREB-binding_protein
RFX5
NF-YA
IRF1
|
|
gptkbp:length
|
1130 amino acids
|
|
gptkbp:locatedOnChromosome
|
16
16p13
|
|
gptkbp:molecularWeight
|
125 kDa
|
|
gptkbp:mutationAssociatedWith
|
MHC class II deficiency
|
|
gptkbp:OMIM
|
600005
|
|
gptkbp:orthologInMouse
|
Ciita
|
|
gptkbp:proteinFamily
|
gptkb:GTP-binding_domain
nuclear localization signal
leucine-rich repeats
acidic activation domain
proline/serine/threonine-rich region
|
|
gptkbp:regulates
|
gptkb:HLA-DQA1
gptkb:HLA-DQB1
gptkb:HLA-DRB1
gptkb:HLA-DRA
yes
HLA-DPA1
HLA-DPB1
induced by interferon-gamma
regulated by IRF1
regulated by NF-Y
regulated by RFX complex
regulated by STAT1
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q13951
|
|
gptkbp:bfsParent
|
gptkb:PRDM1
gptkb:MHC_II
gptkb:MHC_class_II_genes
gptkb:HLA-DRA
gptkb:HLA_class_II_genes
|
|
gptkbp:bfsLayer
|
8
|