IRF4

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias MUM1
LSIRF
MUM1L1
gptkbp:associatedWith leukemia
multiple myeloma
chronic lymphocytic leukemia
gptkbp:biologicalProcess regulation of transcription
DNA binding
immune system process
transcriptional activator activity
gptkbp:cellularComponent gptkb:nucleus
gptkbp:chromosomeArm 6p25.3
gptkbp:discoveredBy T. Tamura et al.
gptkbp:discoveredIn 1994
gptkbp:encodes Interferon regulatory factor 4 protein
gptkbp:Entrez_Gene_ID 3662
ENSG00000137265
gptkbp:expressedIn lymphocytes
gptkbp:fullName Interferon Regulatory Factor 4
gptkbp:function transcription factor
regulation of immune response
gptkbp:HGNC_ID 6122
https://www.w3.org/2000/01/rdf-schema#label IRF4
gptkbp:locatedOnChromosome 6
gptkbp:mutationAssociatedWith immunodeficiency
Waldentrom macroglobulinemia
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse Irf4
gptkbp:proteinFamily gptkb:interferon_regulatory_factor_family
gptkbp:regulates T cell activation
inflammatory response
cytokine production
germinal center formation
B cell differentiation
antibody production
macrophage polarization
plasma cell differentiation
dendritic cell function
Th17 cell differentiation
T cell exhaustion
regulatory T cell function
memory B cell formation
monocyte differentiation
T follicular helper cell development
immune checkpoint expression
immunoglobulin class switch recombination
gptkbp:UniProtID Q15306
gptkbp:bfsParent gptkb:BATF
gptkb:PRDM1
gptkb:basic_leucine_zipper_transcription_factor,_ATF-like
gptkb:PU.1
gptkb:SPI1
gptkbp:bfsLayer 8