Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
MUM1
LSIRF MUM1L1 |
| gptkbp:associatedWith |
gptkb:leukemia
multiple myeloma chronic lymphocytic leukemia |
| gptkbp:biologicalProcess |
regulation of transcription
DNA binding immune system process transcriptional activator activity |
| gptkbp:cellularComponent |
gptkb:nucleus
|
| gptkbp:chromosomeArm |
6p25.3
|
| gptkbp:discoveredBy |
T. Tamura et al.
|
| gptkbp:discoveredIn |
1994
|
| gptkbp:encodes |
Interferon regulatory factor 4 protein
|
| gptkbp:Entrez_Gene_ID |
3662
ENSG00000137265 |
| gptkbp:expressedIn |
lymphocytes
|
| gptkbp:fullName |
Interferon Regulatory Factor 4
|
| gptkbp:function |
gptkb:transcription_factor
regulation of immune response |
| gptkbp:HGNC_ID |
6122
|
| gptkbp:locatedOnChromosome |
6
|
| gptkbp:mutationAssociatedWith |
gptkb:immunodeficiency
Waldentrom macroglobulinemia |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Irf4
|
| gptkbp:proteinFamily |
gptkb:interferon_regulatory_factor_family
|
| gptkbp:regulates |
T cell activation
inflammatory response cytokine production germinal center formation B cell differentiation antibody production macrophage polarization plasma cell differentiation dendritic cell function Th17 cell differentiation T cell exhaustion regulatory T cell function memory B cell formation monocyte differentiation T follicular helper cell development immune checkpoint expression immunoglobulin class switch recombination |
| gptkbp:UniProtID |
Q15306
|
| gptkbp:bfsParent |
gptkb:BATF
gptkb:PRDM1 gptkb:basic_leucine_zipper_transcription_factor,_ATF-like gptkb:PU.1 gptkb:SPI1 |
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
IRF4
|