Statements (54)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:gene
|
gptkbp:alias |
MUM1
LSIRF MUM1L1 |
gptkbp:associatedWith |
leukemia
multiple myeloma chronic lymphocytic leukemia |
gptkbp:biologicalProcess |
regulation of transcription
DNA binding immune system process transcriptional activator activity |
gptkbp:cellularComponent |
gptkb:nucleus
|
gptkbp:chromosomeArm |
6p25.3
|
gptkbp:discoveredBy |
T. Tamura et al.
|
gptkbp:discoveredIn |
1994
|
gptkbp:encodes |
Interferon regulatory factor 4 protein
|
gptkbp:Entrez_Gene_ID |
3662
ENSG00000137265 |
gptkbp:expressedIn |
lymphocytes
|
gptkbp:fullName |
Interferon Regulatory Factor 4
|
gptkbp:function |
transcription factor
regulation of immune response |
gptkbp:HGNC_ID |
6122
|
https://www.w3.org/2000/01/rdf-schema#label |
IRF4
|
gptkbp:locatedOnChromosome |
6
|
gptkbp:mutationAssociatedWith |
immunodeficiency
Waldentrom macroglobulinemia |
gptkbp:organism |
gptkb:Homo_sapiens
|
gptkbp:orthologInMouse |
Irf4
|
gptkbp:proteinFamily |
gptkb:interferon_regulatory_factor_family
|
gptkbp:regulates |
T cell activation
inflammatory response cytokine production germinal center formation B cell differentiation antibody production macrophage polarization plasma cell differentiation dendritic cell function Th17 cell differentiation T cell exhaustion regulatory T cell function memory B cell formation monocyte differentiation T follicular helper cell development immune checkpoint expression immunoglobulin class switch recombination |
gptkbp:UniProtID |
Q15306
|
gptkbp:bfsParent |
gptkb:BATF
gptkb:PRDM1 gptkb:basic_leucine_zipper_transcription_factor,_ATF-like gptkb:PU.1 gptkb:SPI1 |
gptkbp:bfsLayer |
8
|