|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:catalyzes
|
conversion of PIP2 to PIP3
|
|
gptkbp:discoveredBy
|
gptkb:Lewis_Cantley
|
|
gptkbp:EC_number
|
2.7.1.153
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
eukaryotic cells
|
|
gptkbp:function
|
phosphorylates phosphatidylinositol lipids
|
|
gptkbp:gene
|
gptkb:PIK3R1
gptkb:PIK3R2
gptkb:PIK3R3
gptkb:PIK3R5
gptkb:PIK3R6
gptkb:PIK3R4
gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
|
|
gptkbp:GO_term
|
signal transduction
phosphatidylinositol 3-kinase activity
|
|
gptkbp:hasComponent
|
gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
p110 catalytic subunit
p85 regulatory subunit
|
|
gptkbp:hasIsoform
|
gptkb:Class_III_PI3K
gptkb:Class_II_PI3K
gptkb:Class_I_PI3K
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K complex
|
|
gptkbp:inhibitedBy
|
gptkb:Wortmannin
gptkb:LY294002
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
cell survival
metabolism
cancer progression
cell growth regulation
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
immunodeficiency
overgrowth syndromes
|
|
gptkbp:regulates
|
gptkb:mTOR_pathway
AKT activation
|
|
gptkbp:subunit
|
catalytic subunit
regulatory subunit
|
|
gptkbp:target
|
PI3K inhibitors
|
|
gptkbp:bfsParent
|
gptkb:phosphoinositide_3-kinase_complex
gptkb:regulatory_subunit_Vps15
gptkb:PI3K_delta
|
|
gptkbp:bfsLayer
|
6
|