|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:PDK1
gptkb:3-phosphoinositide-dependent_protein_kinase_1
gptkb:Protein_kinase_1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes
obesity
|
|
gptkbp:discoveredBy
|
gptkb:Dario_R_Alessi
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:PDPK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
GC16P002073
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:fullName
|
gptkb:3-phosphoinositide-dependent_protein_kinase-1
|
|
gptkbp:function
|
regulation of cell survival
regulation of cell growth
regulation of metabolism
serine/threonine protein kinase activity
|
|
gptkbp:gene
|
gptkb:PDPK1
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:8816
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDPK1
|
|
gptkbp:interactsWith
|
gptkb:AKT2
gptkb:AKT3
gptkb:PIK3CA
gptkb:PKCdelta
gptkb:PKCzeta
|
|
gptkbp:involvedIn
|
gptkb:PI3K-Akt_signaling_pathway
insulin signaling pathway
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
16p13.3
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:OMIM
|
605213
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1H1W
gptkb:1UU3
2BIY
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
gptkb:S6K
gptkb:SGK1
gptkb:RSK
gptkb:PKC_isoforms
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
gptkb:NP_002604
|
|
gptkbp:regulates
|
activated by PIP3
regulated by phosphorylation
|
|
gptkbp:structure
|
contains PH domain
contains kinase domain
|
|
gptkbp:target
|
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:O15530
|
|
gptkbp:bfsParent
|
gptkb:PDK1
|
|
gptkbp:bfsLayer
|
6
|