3-phosphoinositide-dependent protein kinase-1

URI: https://gptkb.org/entity/3-phosphoinositide-dependent_protein_kinase-1
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkbp:alternativeName gptkb:PDPK1
gptkb:PDK1
gptkbp:associatedWith gptkb:cancer
gptkb:diabetes
obesity
gptkbp:biologicalProcess protein serine/threonine kinase activity
gptkbp:discoveredBy 1997
gptkbp:EC_number 2.7.11.1
gptkbp:encodedBy gptkb:PDPK1_gene
gptkbp:function regulates metabolism
regulates cell survival
phosphorylates and activates AGC family kinases
regulates cell growth
gptkbp:gene gptkb:PDPK1
https://www.w3.org/2000/01/rdf-schema#label 3-phosphoinositide-dependent protein kinase-1
gptkbp:inhibitedBy gptkb:BX-795
gptkb:GSK2334470
gptkbp:locatedOnChromosome 16p13.3
gptkbp:location gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:organism gptkb:Homo_sapiens
gptkbp:pathway gptkb:PI3K/AKT_pathway
gptkbp:structure contains PH domain
contains kinase domain
gptkbp:substrate gptkb:AKT1
gptkb:S6K
gptkb:SGK
gptkb:PKC
gptkbp:UniProtID gptkb:O15530
gptkbp:bfsParent gptkb:PDK1
gptkbp:bfsLayer 6