3-phosphoinositide-dependent protein kinase 1

URI: https://gptkb.org/entity/3-phosphoinositide-dependent_protein_kinase_1
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alsoKnownAs gptkb:PDK1
gptkbp:associatedWith gptkb:cancer
gptkb:diabetes_mellitus
obesity
gptkbp:biologicalProcess gptkb:PI3K-Akt_signaling_pathway
signal transduction
insulin signaling pathway
protein serine/threonine kinase activity
gptkbp:cellularComponent gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:discoveredBy 1997
gptkbp:EC_number 2.7.11.1
gptkbp:encodedBy gptkb:PDPK1_gene
gptkbp:function regulates metabolism
regulates cell survival
phosphorylates and activates AGC family kinases
regulates cell growth
https://www.w3.org/2000/01/rdf-schema#label 3-phosphoinositide-dependent protein kinase 1
gptkbp:inhibitedBy gptkb:BX-795
gptkb:GSK2334470
gptkbp:locatedOnChromosome 16p13.3
gptkbp:organism gptkb:Homo_sapiens
gptkbp:phosphorylates gptkb:S6K
gptkb:SGK
gptkb:PKC
gptkb:Akt1
gptkbp:regulates activated by phosphoinositide lipids
gptkbp:structure contains PH domain
gptkbp:UniProtID gptkb:O15530
gptkbp:bfsParent gptkb:PDPK1
gptkbp:bfsLayer 7