Poly(ADP-ribose) synthetase 1
GPTKB entity
Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:PARP1
gptkb:ADPRT |
| gptkbp:associatedWith |
gptkb:cancer
neurodegeneration |
| gptkbp:cofactor |
Mg2+
|
| gptkbp:discoveredBy |
gptkb:Pierre_Chambon
|
| gptkbp:EC_number |
2.4.2.30
|
| gptkbp:encodedBy |
gptkb:PARP1_gene
|
| gptkbp:Entrez_Gene_ID |
GC01M022425
|
| gptkbp:function |
DNA repair
poly(ADP-ribosyl)ation |
| gptkbp:HGNC_ID |
gptkb:HGNC:270
|
| https://www.w3.org/2000/01/rdf-schema#label |
Poly(ADP-ribose) synthetase 1
|
| gptkbp:inhibitedBy |
PARP inhibitors
|
| gptkbp:involvedIn |
base excision repair
|
| gptkbp:locatedIn |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
chromosome 1q42
|
| gptkbp:molecularWeight |
113 kDa
|
| gptkbp:OMIM |
173870
|
| gptkbp:participatedIn |
transcription regulation
cell death chromatin remodeling |
| gptkbp:product |
poly(ADP-ribose)
|
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
contains catalytic domain
contains BRCT domain contains zinc finger domains |
| gptkbp:substrate |
NAD+
|
| gptkbp:UniProtID |
gptkb:P09874
|
| gptkbp:bfsParent |
gptkb:PARP1
|
| gptkbp:bfsLayer |
7
|