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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
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gptkbp:associatedWith
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gptkb:Li-Fraumeni_syndrome
Various cancers
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gptkbp:database
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gptkb:UniProt
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gptkbp:domain
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DNA-binding domain
Tetramerization domain
Transactivation domain
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gptkbp:Entrez_Gene_ID
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gptkb:ENSP00000269305
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gptkbp:function
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Acts as a tumor suppressor in many tumor types
Involved in DNA repair
Involved in apoptosis
Involved in senescence
Regulates cell cycle
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gptkbp:gene
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gptkb:TP53
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gptkbp:GO
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GO:0003677 (DNA binding)
GO:0008285 (negative regulation of cell proliferation)
GO:0003700 (transcription factor activity)
GO:0006915 (apoptotic process)
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gptkbp:HGNC_ID
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11998
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https://www.w3.org/2000/01/rdf-schema#label
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P20290
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gptkbp:interactsWith
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gptkb:ATR
gptkb:CHEK2
gptkb:CREBBP
gptkb:EP300
gptkb:TP53BP1
gptkb:TP53BP2
gptkb:BAX
gptkb:MDM2
gptkb:BRCA1
ATM
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gptkbp:locatedOnChromosome
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17p13.1
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gptkbp:molecularWeight
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43.7 kDa
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gptkbp:OMIM
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191170
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:pathway
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DNA damage response
Apoptosis
p53 signaling pathway
Cell cycle regulation
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gptkbp:PDB
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gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
5XVK
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gptkbp:postTranslationalModification
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Methylation
Phosphorylation
Acetylation
Ubiquitination
Sumoylation
Neddylation
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gptkbp:protein_name
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gptkb:Cellular_tumor_antigen_p53
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gptkbp:refersTo
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Human protein: Tumor protein p53
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gptkbp:RefSeq
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NP_000537.3
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gptkbp:reviewedBy
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Yes
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gptkbp:sequence
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393
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gptkbp:structure
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Tetramer
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gptkbp:subcellularLocation
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gptkb:Mitochondrion
gptkb:Nucleus
gptkb:Cytoplasm
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gptkbp:UniProt_entry_name
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gptkb:P53_HUMAN
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gptkbp:bfsParent
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gptkb:TFIIB
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gptkbp:bfsLayer
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7
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