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gptkbp:instanceOf
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gptkb:UniProt_accession_number
|
|
gptkbp:alternativeName
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gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
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gptkbp:associatedWith
|
gptkb:Li-Fraumeni_syndrome
Various cancers
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gptkbp:database
|
gptkb:UniProt
|
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gptkbp:domain
|
DNA-binding domain
Tetramerization domain
Transactivation domain
|
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gptkbp:Entrez_Gene_ID
|
gptkb:ENSP00000269305
|
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gptkbp:function
|
Acts as a tumor suppressor in many tumor types
Involved in DNA repair
Involved in apoptosis
Involved in senescence
Regulates cell cycle
|
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gptkbp:gene
|
gptkb:TP53
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gptkbp:GO
|
GO:0003677 (DNA binding)
GO:0008285 (negative regulation of cell proliferation)
GO:0003700 (transcription factor activity)
GO:0006915 (apoptotic process)
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gptkbp:HGNC_ID
|
11998
|
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gptkbp:interactsWith
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gptkb:ATR
gptkb:CHEK2
gptkb:CREBBP
gptkb:EP300
gptkb:TP53BP1
gptkb:TP53BP2
gptkb:BAX
gptkb:MDM2
gptkb:BRCA1
gptkb:ATM
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:pathway
|
DNA damage response
Apoptosis
p53 signaling pathway
Cell cycle regulation
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
gptkb:4HJE
1TUP
5XVK
|
|
gptkbp:postTranslationalModification
|
Methylation
Phosphorylation
Acetylation
Ubiquitination
Sumoylation
Neddylation
|
|
gptkbp:protein_name
|
gptkb:Cellular_tumor_antigen_p53
|
|
gptkbp:refersTo
|
Human protein: Tumor protein p53
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:reviewedBy
|
Yes
|
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gptkbp:sequence
|
393
|
|
gptkbp:structure
|
Tetramer
|
|
gptkbp:subcellularLocation
|
gptkb:Mitochondrion
gptkb:Nucleus
gptkb:Cytoplasm
|
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gptkbp:UniProt_entry_name
|
gptkb:P53_HUMAN
|
|
gptkbp:bfsParent
|
gptkb:TFIIB
|
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gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P20290
|