|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Cytochrome_P450_3A4
gptkb:Cytochrome_P450_DB1
gptkb:CYP3A4
P450-DB1
|
|
gptkbp:biologicalProcess
|
monooxygenase activity
drug metabolism
xenobiotic metabolism
|
|
gptkbp:cellularComponent
|
endoplasmic reticulum membrane
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:encodedBy
|
gptkb:CYP3A4_gene
|
|
gptkbp:Entrez_Gene_ID
|
1576
ENSP00000361930
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.1
|
|
gptkbp:expressedIn
|
liver
intestine
|
|
gptkbp:family
|
gptkb:cytochrome_P450
|
|
gptkbp:function
|
metabolism of xenobiotics
drug clearance
oxidation of small molecules
|
|
gptkbp:gene
|
gptkb:CYP3A4
|
|
gptkbp:HGNC_ID
|
2626
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P08684 (CYP3A4)
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
gptkb:St._John's_Wort
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:clarithromycin
gptkb:ketoconazole
itraconazole
|
|
gptkbp:KEGGID
|
hsa:1576
|
|
gptkbp:length
|
503
|
|
gptkbp:locatedOnChromosome
|
7q22.1
|
|
gptkbp:molecularWeight
|
57390 Da
|
|
gptkbp:OMIM
|
124010
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:3NXU
gptkb:5TE8
1TQN
4D6Z
|
|
gptkbp:Reactome
|
R-HSA-211958
|
|
gptkbp:RefSeq
|
gptkb:NP_017539.1
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
microsome
|
|
gptkbp:substrate
|
gptkb:cyclosporine
gptkb:warfarin
gptkb:nifedipine
gptkb:omeprazole
gptkb:lidocaine
gptkb:tamoxifen
gptkb:carbamazepine
gptkb:erythromycin
gptkb:midazolam
statins
alprazolam
testosterone
|
|
gptkbp:tissue_specificity
|
gptkb:breast
gptkb:cancer
gptkb:skeletal_muscle
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
gptkb:thymus
brain
heart
liver
spleen
colon
pancreas
uterus
|
|
gptkbp:UniProtID
|
P08684
|
|
gptkbp:bfsParent
|
gptkb:CYP3A
|
|
gptkbp:bfsLayer
|
6
|