|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Lymphocyte-specific_protein_tyrosine_kinase
p56lck
|
|
gptkbp:associatedWith
|
gptkb:Severe_combined_immunodeficiency
Lymphoma
Leukemia
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSP00000361789
3932
|
|
gptkbp:enzymeClassification
|
EC 2.7.10.2
|
|
gptkbp:function
|
Non-receptor tyrosine-protein kinase involved in T-cell receptor signaling
|
|
gptkbp:hasGeneCardsID
|
gptkb:LCK
|
|
gptkbp:hasGeneName
|
gptkb:LCK
|
|
gptkbp:hasRefSeqProteinID
|
NP_005347.1
|
|
gptkbp:HGNC_ID
|
HGNC:6524
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P06276
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:VAV1
gptkb:PTPN6
gptkb:CD247
gptkb:CD3G
gptkb:CD4
gptkb:CSK
gptkb:CD8A
gptkb:CD3D
gptkb:CD3E
gptkb:CD3Z
gptkb:LIME1
gptkb:SH2D1A
gptkb:ZAP70
FYN
|
|
gptkbp:KEGGID
|
hsa:3932
|
|
gptkbp:length
|
509 amino acids
|
|
gptkbp:locatedOnChromosome
|
1
1p35.3-p34.1
|
|
gptkbp:molecularWeight
|
58,000 Da
|
|
gptkbp:OMIM
|
153390
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:T_cell_receptor_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:Calcium_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:1QPC
gptkb:2PL0
gptkb:3LCK
4D8K
|
|
gptkbp:postTranslationalModification
|
Palmitoylation
Phosphorylation
Myristoylation
|
|
gptkbp:protein_name
|
gptkb:Tyrosine-protein_kinase_Lck
|
|
gptkbp:Reactome
|
R-HSA-202430
|
|
gptkbp:subcellularLocation
|
gptkb:Nucleus
gptkb:Cell_membrane
gptkb:Cytoplasm
|
|
gptkbp:tissue_specificity
|
gptkb:T-lymphocytes
|
|
gptkbp:UniProtID
|
gptkb:P06276
|
|
gptkbp:bfsParent
|
gptkb:BCHE
gptkb:butyrylcholinesterase
|
|
gptkbp:bfsLayer
|
7
|