Lymphocyte-specific protein tyrosine kinase

URI: https://gptkb.org/entity/Lymphocyte-specific_protein_tyrosine_kinase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName p56lck
LCK proto-oncogene, Src family tyrosine kinase
gptkbp:belongs_to_protein_family gptkb:Src_family_kinases
gptkbp:biologicalProcess gptkb:T_cell_receptor_signaling_pathway
immune response
protein tyrosine kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:enzymeCommissionNumber 2.7.10.2
gptkbp:expressedIn gptkb:natural_killer_cells
T lymphocytes
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function signal transduction
T cell activation
gptkbp:gene gptkb:LCK
https://www.w3.org/2000/01/rdf-schema#label Lymphocyte-specific protein tyrosine kinase
gptkbp:interactsWith gptkb:T_cell_receptor_complex
gptkb:CD4
gptkb:CD8
gptkbp:locatedOnChromosome gptkb:chromosome_1q32
gptkbp:molecularWeight 56 kDa
gptkbp:PDB gptkb:3LCK
gptkbp:phosphorylates gptkb:ZAP-70
gptkb:CD3_zeta_chain
gptkbp:regulates regulated by phosphorylation
gptkbp:significance implicated in leukemia
gptkbp:UniProtID P06239
gptkbp:bfsParent gptkb:P06276
gptkb:Lck
gptkbp:bfsLayer 8