|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Cluster_of_Differentiation_4
|
|
gptkbp:antibodyTarget
|
gptkb:Leu-3
gptkb:OKT4
gptkb:RPA-T4
|
|
gptkbp:biologicalProcess
|
immune system process
MHC class II protein binding
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Ellis_Reinherz
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodedBy
|
gptkb:CD4_gene
|
|
gptkbp:Entrez_Gene_ID
|
920
ENSG00000010610
|
|
gptkbp:expressedIn
|
gptkb:thymus
lymph nodes
spleen
peripheral blood
|
|
gptkbp:foundIn
|
dendritic cells
macrophages
monocytes
T helper cells
surface of immune cells
|
|
gptkbp:function
|
binds to MHC class II molecules
co-receptor for T cell receptor
|
|
gptkbp:glycoprotein
|
yes
|
|
gptkbp:HGNC_ID
|
1678
|
|
gptkbp:HIVEntryReceptor
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD4
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:mutationAssociatedWith
|
autoimmune diseases
immunodeficiency
HIV susceptibility
|
|
gptkbp:OMIM
|
186940
|
|
gptkbp:PDB
|
1CDH
|
|
gptkbp:roleInImmunity
|
helps activate B cells
helps activate cytotoxic T cells
initiates immune response
regulates immune response
stimulates macrophages
|
|
gptkbp:significance
|
CD4 count used to monitor HIV/AIDS progression
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
single-chain glycoprotein
|
|
gptkbp:target
|
gptkb:HIV
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P01730
|
|
gptkbp:usedAs
|
marker for T helper cells
|
|
gptkbp:bfsParent
|
gptkb:T-cell_ALL
gptkb:cell_surface_receptor
gptkb:TCR
gptkb:Papito_Edición_Especial_6CD
gptkb:T-cells
gptkb:CD4+_T_cells
gptkb:HIV-1
gptkb:Human_Immunodeficiency_Virus
|
|
gptkbp:bfsLayer
|
6
|