Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
glutamate
serine histidine |
| gptkbp:alternativeName |
gptkb:plasma_cholinesterase
gptkb:pseudocholinesterase |
| gptkbp:catalyzes |
hydrolysis of choline-based esters
|
| gptkbp:clinical_use |
assessment of exposure to nerve agents
diagnosis of liver function identification of atypical enzyme variants |
| gptkbp:cofactor |
none required
|
| gptkbp:EC_number |
3.1.1.8
|
| gptkbp:family |
serine hydrolase
|
| gptkbp:firstDescribed |
1940
|
| gptkbp:foundIn |
blood plasma
|
| gptkbp:gene |
gptkb:BCHE
|
| gptkbp:HGNC_ID |
1038
|
| https://www.w3.org/2000/01/rdf-schema#label |
butyrylcholinesterase
|
| gptkbp:inhibitedBy |
gptkb:organophosphates
carbamates |
| gptkbp:involves |
drug metabolism
cocaine hydrolysis succinyldicholine metabolism |
| gptkbp:locatedOnChromosome |
gptkb:3q26.1-q26.2
|
| gptkbp:location |
gptkb:skin
gptkb:kidney heart lungs gastrointestinal tract central nervous system liver spleen white matter of brain |
| gptkbp:molecularWeight |
340 kDa (tetramer)
|
| gptkbp:mutationAssociatedWith |
atypical enzyme variants
increased sensitivity to certain anesthetics prolonged apnea after succinylcholine |
| gptkbp:OMIM |
177400
|
| gptkbp:PDB |
1P0I
|
| gptkbp:structure |
tetramer
|
| gptkbp:substrate |
gptkb:acetylcholine
gptkb:butyrylcholine |
| gptkbp:UniProtID |
gptkb:P06276
|
| gptkbp:used_in |
biochemical research
clinical diagnostics forensic toxicology |
| gptkbp:usedFor |
bioscavenger for organophosphate poisoning
|
| gptkbp:bfsParent |
gptkb:Cholinesterase
|
| gptkbp:bfsLayer |
6
|