|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
immunodeficiency
autoimmune disease
chronic lymphocytic leukemia
ZAP70 deficiency
|
|
gptkbp:discoveredBy
|
André Veillette
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
ZAP70 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ZAP70
ENSG00000115085
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:T_cells
|
|
gptkbp:fullName
|
Zeta-chain-associated protein kinase 70
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
T-cell receptor signaling
|
|
gptkbp:gene
|
gptkb:ZAP70
|
|
gptkbp:GO
|
gptkb:GO:0004713
gptkb:GO:0007259
GO:0007169
|
|
gptkbp:HGNC_ID
|
12862
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ZAP70
|
|
gptkbp:interactsWith
|
gptkb:CD3_complex
gptkb:Lck
gptkb:TCR_complex
|
|
gptkbp:KEGGID
|
hsa:7535
|
|
gptkbp:location
|
chromosome 2q12
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:mutationAssociatedWith
|
SCID-like phenotype
immunodeficiency syndrome
|
|
gptkbp:OMIM
|
176947
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1U59
|
|
gptkbp:phosphorylates
|
gptkb:LAT
gptkb:SLP-76
TCR zeta chain
|
|
gptkbp:RefSeq
|
NM_001079
|
|
gptkbp:reviewedBy
|
gptkb:Immunity
gptkb:Nature
Cell
|
|
gptkbp:structure
|
contains kinase domain
contains SH2 domains
|
|
gptkbp:UniProtID
|
P43403
|
|
gptkbp:bfsParent
|
gptkb:ZAP-70
|
|
gptkbp:bfsLayer
|
7
|