Docetaxel

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf antineoplastic agent
taxane
gptkbp:administeredBy intravenous infusion
gptkbp:approvalYear 1996
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode gptkb:L01CD02
gptkbp:brand gptkb:Taxotere
gptkbp:CASNumber gptkb:114977-28-5
gptkbp:category mitotic inhibitor
plant alkaloid
antimitotic agent
gptkbp:chemicalFormula C43H53NO14
gptkbp:contraindication severe liver impairment
gptkbp:derivedFrom gptkb:European_yew_tree_(Taxus_baccata)
gptkbp:developedBy gptkb:Aventis
gptkbp:discoveredBy gptkb:Rhodia
gptkbp:eliminationHalfLife 11 hours
gptkbp:firstSynthesized 1986
gptkbp:genericAvailable yes
https://www.w3.org/2000/01/rdf-schema#label Docetaxel
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits microtubule depolymerization
gptkbp:metabolism liver
gptkbp:molecularWeight 807.88 g/mol
gptkbp:origin semi-synthetic derivative of 10-deacetylbaccatin III
gptkbp:patentExpired 2010
gptkbp:pregnancyCategory D (US)
gptkbp:PubChem_CID gptkb:CHEMBL178
gptkb:DB01248
148124
gptkbp:requiresPremedication corticosteroids
gptkbp:riskOfHypersensitivity yes
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
fatigue
hair loss
peripheral neuropathy
neutropenia
fluid retention
gptkbp:solubility practically insoluble in water
gptkbp:storage 2–8°C
gptkbp:UNII 699121PHCA
gptkbp:usedFor gptkb:non-small_cell_lung_cancer
gptkb:cancer
prostate cancer
head and neck cancer
gastric cancer
gptkbp:WHOModelListOfEssentialMedicines included
gptkbp:bfsParent gptkb:Non-Small_Cell_Lung_Cancer
gptkbp:bfsLayer 6