gptkbp:instanceOf
|
antineoplastic agent
taxane
|
gptkbp:administeredBy
|
intravenous infusion
|
gptkbp:approvalYear
|
1996
|
gptkbp:approvedBy
|
gptkb:FDA
|
gptkbp:ATCCode
|
gptkb:L01CD02
|
gptkbp:brand
|
gptkb:Taxotere
|
gptkbp:CASNumber
|
gptkb:114977-28-5
|
gptkbp:category
|
mitotic inhibitor
plant alkaloid
antimitotic agent
|
gptkbp:chemicalFormula
|
C43H53NO14
|
gptkbp:contraindication
|
severe liver impairment
|
gptkbp:derivedFrom
|
gptkb:European_yew_tree_(Taxus_baccata)
|
gptkbp:developedBy
|
gptkb:Aventis
|
gptkbp:discoveredBy
|
gptkb:Rhodia
|
gptkbp:eliminationHalfLife
|
11 hours
|
gptkbp:firstSynthesized
|
1986
|
gptkbp:genericAvailable
|
yes
|
https://www.w3.org/2000/01/rdf-schema#label
|
Docetaxel
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
inhibits microtubule depolymerization
|
gptkbp:metabolism
|
liver
|
gptkbp:molecularWeight
|
807.88 g/mol
|
gptkbp:origin
|
semi-synthetic derivative of 10-deacetylbaccatin III
|
gptkbp:patentExpired
|
2010
|
gptkbp:pregnancyCategory
|
D (US)
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL178
gptkb:DB01248
148124
|
gptkbp:requiresPremedication
|
corticosteroids
|
gptkbp:riskOfHypersensitivity
|
yes
|
gptkbp:routeOfAdministration
|
intravenous
|
gptkbp:sideEffect
|
nausea
fatigue
hair loss
peripheral neuropathy
neutropenia
fluid retention
|
gptkbp:solubility
|
practically insoluble in water
|
gptkbp:storage
|
2–8°C
|
gptkbp:UNII
|
699121PHCA
|
gptkbp:usedFor
|
gptkb:non-small_cell_lung_cancer
gptkb:cancer
prostate cancer
head and neck cancer
gastric cancer
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
gptkbp:bfsParent
|
gptkb:Non-Small_Cell_Lung_Cancer
|
gptkbp:bfsLayer
|
6
|