Cisplatin

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
antineoplastic agent
World Health Organization essential medicine
platinum-based drug
gptkbp:approvedBy 1978
gptkbp:ATCCode L01XA01
gptkbp:CASNumber 15663-27-1
gptkbp:chemicalFormula Cl2H6N2Pt
gptkbp:color yellow
gptkbp:crystalSystem orthorhombic
gptkbp:discoveredBy gptkb:Michele_Peyrone
gptkbp:discoveredIn gptkb:Italy
1845
gptkbp:eliminationHalfLife 20–30 hours
gptkbp:excretion renal
gptkbp:firstClinicalUse 1971
https://www.w3.org/2000/01/rdf-schema#label Cisplatin
gptkbp:isomerOf gptkb:transplatin
gptkbp:IUPACName gptkb:cis-diamminedichloroplatinum(II)
gptkbp:KEGGID D00275
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction DNA crosslinking
inhibition of DNA synthesis
gptkbp:meltingPoint 270 °C (decomposes)
gptkbp:metabolism non-enzymatic
gptkbp:molecularWeight 300.05 g/mol
gptkbp:pregnancyCategory D (US)
gptkbp:PubChem_CID CHEMBL1377
441203
CHEBI:27899
DB00515
gptkbp:relatedTo gptkb:carboplatin
gptkb:oxaliplatin
gptkb:nedaplatin
gptkb:satraplatin
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
vomiting
nephrotoxicity
neurotoxicity
ototoxicity
myelosuppression
electrolyte disturbances
gptkbp:solubility 2.53 g/L (25 °C)
gptkbp:UNII Q20Q21Q62J
gptkbp:usedForTreatmentOf gptkb:cancer
colorectal cancer
esophageal cancer
testicular cancer
bladder cancer
head and neck cancer
gastric cancer
gptkbp:bfsParent gptkb:Non-Small_Cell_Lung_Cancer
gptkbp:bfsLayer 6