Vinorelbine

URI: https://gptkb.org/entity/Vinorelbine

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound antineoplastic agent mitotic inhibitor vinca alkaloid
gptkbp:approvalYear	1994
gptkbp:approvedBy	gptkb:FDA
gptkbp:ATCCode	L01CA04
gptkbp:CASNumber	71486-22-1
gptkbp:category	antimitotic agent
gptkbp:chemicalFormula	C45H54N4O8
gptkbp:contraindication	severe hepatic impairment severe neutropenia
gptkbp:derivedFrom	gptkb:Catharanthus_roseus
gptkbp:developedBy	gptkb:Pierre_Fabre_Laboratories
gptkbp:discoveredBy	gptkb:Pierre_Potier
gptkbp:eliminationHalfLife	27.7-43.6 hours
gptkbp:excretion	urine bile
https://www.w3.org/2000/01/rdf-schema#label	Vinorelbine
gptkbp:IUPACName	(1S,9S,10R,12R,15R,19R)-15-acetoxy-19-ethyl-9-(methoxycarbonyl)-10,12-dimethoxy-1,2,3,4,6,7,8,9,10,11,12,13,14,15,16,17,18,19-octadecahydro-1,19-epoxy-10,15:12,19-dimethano-3H,17H-pyrido[2,1-c][1,5]benzodiazacyclooctadecine-17,20-dione
gptkbp:KEGGID	D08670
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits microtubule assembly
gptkbp:metabolism	liver
gptkbp:molecularWeight	778.94 g/mol
gptkbp:origin	semi-synthetic derivative of vinca alkaloids
gptkbp:pregnancy_risk	teratogenic
gptkbp:pregnancyCategory	D (US)
gptkbp:PubChem_CID	gptkb:CHEMBL1426 33413 36314 DB00361
gptkbp:routeOfAdministration	oral intravenous
gptkbp:sideEffect	nausea vomiting constipation fatigue neutropenia
gptkbp:synonym	gptkb:Eldisine gptkb:Navelbine
gptkbp:UNII	6E3Z5PCO1S
gptkbp:usedFor	gptkb:non-small_cell_lung_cancer gptkb:cancer
gptkbp:bfsParent	gptkb:Non-Small_Cell_Lung_Cancer
gptkbp:bfsLayer	6