Paclitaxel

URI: https://gptkb.org/entity/Paclitaxel

GPTKB entity

Statements (54)

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound antineoplastic agent mitotic inhibitor plant-derived compound
gptkbp:alternative_formulation	gptkb:albumin-bound_paclitaxel nanoparticle formulation
gptkbp:ATCCode	L01CD01
gptkbp:brand	gptkb:Taxol
gptkbp:CASNumber	33069-62-4
gptkbp:category	natural product antineoplastic agent microtubule inhibitor
gptkbp:chemicalFormula	C47H51NO14
gptkbp:derivedFrom	gptkb:Pacific_yew_tree
gptkbp:discoveredBy	gptkb:Mansukh_C._Wani gptkb:Monroe_E._Wall
gptkbp:discoveredIn	1971
gptkbp:eliminationHalfLife	5.8 to 24 hours
gptkbp:first_FDA_approval	1992
gptkbp:firstIsolatedFrom	bark of Taxus brevifolia
gptkbp:hasSMILES	CC1=C2C(=CC(=C1OC)OC)C[C@@H]3[C@@H]2[C@H](OC(=O)C)[C@@H](OC(=O)C4=CC=CC=C4)[C@H](O)[C@H](OC(=O)C5=CC=CC=C5)[C@H]3O
https://www.w3.org/2000/01/rdf-schema#label	Paclitaxel
gptkbp:IUPACName	(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-11-acetoxy-12-(benzoyloxy)-1,2a,6,9,12,12a-hexahydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-5H,7H,12bH-4,11-methanobenzofuro[3,4-d][1,3]dioxol-9-yl benzoate
gptkbp:KEGGID	D05367
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits cell division stabilizes microtubules
gptkbp:metabolism	gptkb:CYP2C8 gptkb:CYP3A4 liver
gptkbp:molecularWeight	853.9 g/mol
gptkbp:patentExpired	2000
gptkbp:pregnancyCategory	D (US)
gptkbp:producedBy	gptkb:Taxus_brevifolia
gptkbp:PubChem_CID	gptkb:CHEMBL92 33407 36314 DB01229
gptkbp:relatedTo	docetaxel
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	nausea hair loss peripheral neuropathy neutropenia allergic reactions
gptkbp:solubility	practically insoluble in water
gptkbp:UNII	P88XT4IS4D
gptkbp:usedFor	gptkb:cancer gptkb:Kaposi's_sarcoma pancreatic cancer
gptkbp:WHOModelListOfEssentialMedicines	yes
gptkbp:bfsParent	gptkb:Non-Small_Cell_Lung_Cancer gptkb:Taxol
gptkbp:bfsLayer	6