Toripalimab

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:monoclonal_antibody
immunotherapy
gptkbp:administeredBy chemotherapy
gptkbp:approvalYear 2018
2023-10-27
gptkbp:approvedBy gptkb:nasopharyngeal_carcinoma
gptkb:China
gptkb:United_States
melanoma
gptkbp:associatedWith gptkb:pembrolizumab
gptkb:cemiplimab
gptkb:nivolumab
gptkbp:ATCCode L01FF11
gptkbp:brand gptkb:Loqtorzi
Tuoyi
gptkbp:CASNumber 1925026-50-6
gptkbp:clinicalTrialPhase gptkb:NCT02915432
gptkb:NCT03013101
gptkb:NCT03581786
Phase III
gptkbp:developedBy gptkb:Coherus_BioSciences
gptkb:Shanghai_Junshi_Biosciences
gptkbp:EMAStatus not approved (as of 2024)
gptkbp:halfLife ~17 days
https://www.w3.org/2000/01/rdf-schema#label Toripalimab
gptkbp:indication gptkb:advanced_melanoma
other solid tumors (investigational)
unresectable or metastatic nasopharyngeal carcinoma
gptkbp:legalStatus prescription only
gptkbp:macromoleculeType IgG4 monoclonal antibody
gptkbp:mechanismOfAction immunotherapy
gptkbp:molecularWeight ~146 kDa
gptkbp:monitors oncologist
gptkbp:origin humanized antibody
gptkbp:prescribes adults
pediatric patients (in some indications)
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect diarrhea
fatigue
pruritus
hepatitis
rash
pneumonitis
immune-related adverse events
endocrinopathies
gptkbp:storage refrigerated
gptkbp:target gptkb:PD-1
gptkbp:UNII 6K7C6QFW2K
gptkbp:bfsParent gptkb:Non-Small_Cell_Lung_Cancer
gptkbp:bfsLayer 6